@article{oai:kanazawa-u.repo.nii.ac.jp:00013031,
 author = {Miyawaki, Toshio and Kasahara, Yoshihito and Taga, Kazuyuki and Yachie, Akihiro and Taniguchi, Noboru},
 issue = {5},
 journal = {Journal of Experimental Medicine},
 month = {Jan},
 note = {We examined the developmental profile of TCR-γ/δ+ cells with respect to CD45RO expression. Although total TCR-γ/δ+ cells were negligible in the neonatal blood and increased with advancing age, most blood TCR-γ/δ+ cells markedly expressed CD45RO without a distinction of age, probably reflecting a different CD45RO expression of two subsets defined by BB3 and δTCS1 mAbs. The vast majority of BB3+ cells expressed CD45RO, whereas expression of CD45RO was virtually absent in the δTCS1+ population. Functional studies revealed that, while both TCR-γ/δ+ cell subsets showed CD3-mediated activation, only BB3+ (or TiγA+) cells, but not δTCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals. The results suggested that the CD45RO+ (BB3+ or TiγA+) subset among blood TCR-γ/δ+ cells may be mainly involved in the memory or primed component of the immune system responding to some foreign antigens., 金沢大学大学院医学系研究科血管病態制御学},
 pages = {1833--1838},
 title = {Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-γ/δ+ lymphocytes},
 volume = {171},
 year = {1990}
}