@article{oai:kanazawa-u.repo.nii.ac.jp:00013039, author = {鷲山, 幸信 and 天野, 良平 and 絹谷, 清剛 and 利波, 紀久 and Washiyama, Kohshin and Amano, Ryohei and Sasaki, Jun and Kinuya, Seigo and Tonami, Norihisa and Shiokawa, Yoshinobu and Mitsugashira, Toshiaki}, issue = {7}, journal = {Nuclear Medicine and Biology}, month = {Oct}, note = {The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis., 金沢大学大学院医学系研究科保健学専攻}, pages = {901--908}, title = {227Th-EDTMP: A potential therapeutic agent for bone metastasis}, volume = {31}, year = {2004} }