@article{oai:kanazawa-u.repo.nii.ac.jp:00013050,
 author = {Yagi, Kunimasa and Hifumi, Senshu and Nohara, Atsushi and Higashikata, Toshinori and Inazu, Akihiro and Mizuno, Kiyoo and Namura, Masanobu and Ueda, Kosei and Kobayashi, Junji and Shimizu, Masami and Mabuchi, Hiroshi},
 issue = {7},
 journal = {Circulation Journal},
 month = {Jul},
 note = {Background: The aim of the present study was to clarify the risk factors of several types of arteriosclerosis lesions in Japanese individuals with heterozygous familial hypercholesterolemia (FH): renal arteriosclerosis (RAS), abdominal aortic sclerosis (AOS), iliac arteriosclerosis (IAS) and coronary artery disease (CAD). Methods and Results: Coronary angiography (CAG) and abdominal aortic angiography (AAA) were performed in 117 consecutive heterozygous FH subjects (79 men, 38 women; age 22-76). RAS (stenotic lesion or aneurysm) was observed in 39 cases (33%), predominantly in the proximal portion (74%) and both sides equally (right/left=27/23). Most cases of RAS (64%) presented with <25% stenosis. The differences in the contributing risk factors for the progression and development of RAS, AOS, IAS and CAD in FH were then analyzed. Multiple logistic regression analyses showed independent risk factors for formation of atherosclerosis in each artery were: age alone for RAS; age and plasma low-density lipoprotein cholesterol (LDL-C) for AOS; age, LDL-C and high-density lipoprotein cholesterol (HDL-C) for IAS; and HDL-C and diabetes mellitus for CAD. Conclusion: In Japanese subjects with heterozygous FH, there are distinct risk factors for the development and progression of atherosclerosis in the renal, iliac, abdominal aorta, and coronary arteries., 金沢大学大学院医学系研究科},
 pages = {623--627},
 title = {Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia},
 volume = {68},
 year = {2004}
}