@article{oai:kanazawa-u.repo.nii.ac.jp:00013070,
 author = {Kinoshita, Keita and Ura, Hiroki and Akagi, Tadayuki and Usuda, Masayuki and Koide, Hiroshi and Yokota, Takashi},
 issue = {3},
 journal = {Biochemical and Biophysical Research Communications},
 month = {Feb},
 note = {Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts, and transcription factors Oct-3/4, Nanog, Sox2, and STAT3, are essential for their self-renewal. In this study, we searched for molecules downstream of STAT3 in ES cells. Using DNA chip analysis, we obtained GA-repeat binding protein (GABP) α. Expression of GABPα was restricted to undifferentiated ES cells and controlled by STAT3. We found that the expression level of Oct-3/4 is reduced by knockdown of GABPα. On the other hand, GABPα-overexpressing ES cells maintained the expression level of Oct-3/4 even in the absence of LIF. Moreover, the induction of Oct-3/4 repressors Cdx-2, Coup-tf1, and GCNF was stimulated by GABPα knockdown. These data suggest that GABPα upregulates the expression of Oct-3/4 via downregulation of Oct-3/4 repressors. © 2006 Elsevier Inc. All rights reserved., 金沢大学大学院医学系研究科機能再生学},
 pages = {686--691},
 title = {GABPα regulates Oct-3/4 expression in mouse embryonic stem cells},
 volume = {353},
 year = {2007}
}