{"created":"2023-07-27T06:28:29.364101+00:00","id":13070,"links":{},"metadata":{"_buckets":{"deposit":"1278f081-8c91-47a0-a157-01e548649732"},"_deposit":{"created_by":3,"id":"13070","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13070"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013070","sets":["1132:1133:1134"]},"author_link":["20602","20603","41","84","20604","490"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"691","bibliographicPageStart":"686","bibliographicVolumeNumber":"353","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts, and transcription factors Oct-3/4, Nanog, Sox2, and STAT3, are essential for their self-renewal. In this study, we searched for molecules downstream of STAT3 in ES cells. Using DNA chip analysis, we obtained GA-repeat binding protein (GABP) α. Expression of GABPα was restricted to undifferentiated ES cells and controlled by STAT3. We found that the expression level of Oct-3/4 is reduced by knockdown of GABPα. On the other hand, GABPα-overexpressing ES cells maintained the expression level of Oct-3/4 even in the absence of LIF. Moreover, the induction of Oct-3/4 repressors Cdx-2, Coup-tf1, and GCNF was stimulated by GABPα knockdown. These data suggest that GABPα upregulates the expression of Oct-3/4 via downregulation of Oct-3/4 repressors. © 2006 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科機能再生学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2006.12.071","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ura, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akagi, Tadayuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Usuda, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koide, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yokota, Takashi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-YOKOTA-T-686.fdf","filesize":[{"value":"5.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/octet-stream","url":{"label":"ME-PR-YOKOTA-T-686.fdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13070/files/ME-PR-YOKOTA-T-686.fdf"},"version_id":"af1c0051-c1db-4afb-bbe9-6ca6d7ec6b8c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GABPα regulates Oct-3/4 expression in mouse embryonic stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GABPα regulates Oct-3/4 expression in mouse embryonic stem cells"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13070","relation_version_is_last":true,"title":["GABPα regulates Oct-3/4 expression in mouse embryonic stem cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:21:23.225782+00:00"}