{"created":"2023-07-27T06:28:30.132056+00:00","id":13088,"links":{},"metadata":{"_buckets":{"deposit":"13913692-6266-49ad-bf14-eeb7128df281"},"_deposit":{"created_by":3,"id":"13088","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13088"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013088","sets":["1132:1133:1134"]},"author_link":["20706","20436","20705","20434","20704","20707","20703"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1424","bibliographicPageStart":"1419","bibliographicVolumeNumber":"172","bibliographic_titles":[{"bibliographic_title":"Journal of Experimental Medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科血管病態制御学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Rockefeller University Press"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1084/jem.172.5.1419","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00697559","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-1007","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kasahara, Yoshihito"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyawaki, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Kimitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanegane, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yachie, Akihiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yokoi, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniguchi, Noboru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KASAHARA-Y-1419.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KASAHARA-Y-1419.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13088/files/ME-PR-KASAHARA-Y-1419.pdf"},"version_id":"9944591c-5ac7-45ed-9959-e8a387855f12"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13088","relation_version_is_last":true,"title":["Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:50:00.117938+00:00"}