{"created":"2023-07-27T06:28:30.769759+00:00","id":13103,"links":{},"metadata":{"_buckets":{"deposit":"dbc77e6a-a862-48e7-bf3e-06b471dac5cd"},"_deposit":{"created_by":3,"id":"13103","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13103"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013103","sets":["1132:1133:1134"]},"author_link":["20762","20760","20757","20266","20761","20759","20758","389"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"613","bibliographicPageStart":"609","bibliographicVolumeNumber":"308","bibliographic_titles":[{"bibliographic_title":"New England Journal of Medicine"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We studied the effects of the bile acid sequestrant cholestyramine, alone and in combination with the experimental agent compactin (ML-236B), a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on serum levels of lipoproteins in 10 heterozygous patients with familial hypercholesterolemia. After cholestyramine treatment alone for 2 to 16 months, serum total and low-density lipoprotein cholesterol decreased by 20 and 28 per cent, respectively. With the addition of compactin for 12 weeks there was a 39 per cent total decrease in serum cholesterol from the control value - from 356 ± 14 to 217 ± 10 mg per deciliter (9.27 ± 0.36 to 5.64 ± 0.26 nmol per liter [mean ± S.E.M.]; P < 0.001) - and a 53 per cent decrease in low-density lipoprotein cholesterol - from 263 ± 13 to 125 ± 10 mg per deciliter (6.84 ± 0.34 to 3.25 ± 0.26 nmol per liter; P < 0.001). High-density lipoprotein cholesterol, which had increased during cholestyramine treatment, remained at its higher level. No adverse effects were observed. If long-term safety can be demonstrated, the compactin-cholestyramine regimen may prove useful in heterozygous familial hypercholesterolemia.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Massachusetts Medical Society"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1056/nejm198303173081101","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00755156","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0028-4793","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mabuchi, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sakai, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimura, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakasugi, Takanobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Junji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Takeda, Ryoyu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MABUCHI-H-609.pdf","filesize":[{"value":"545.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MABUCHI-H-609.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13103/files/ME-PR-MABUCHI-H-609.pdf"},"version_id":"1f3da3b1-e97c-43eb-a18f-8964aaac7d7e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13103","relation_version_is_last":true,"title":["Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:27:34.016650+00:00"}