@article{oai:kanazawa-u.repo.nii.ac.jp:00013104,
 author = {Matsuzaki, Masunori and Kita, Toru and Mabuchi, Hiroshi and Matsuzawa, Yuji and Nakaya, Noriaki and Oikawa, Shinichi and Saito, Yasushi and Sasaki, Jun and Shimamoto, Kazuaki and Itakura, Hiroshige},
 issue = {12},
 journal = {Circulation Journal},
 month = {Dec},
 note = {Hyperlipidemia is a well-established risk factor for primary coronary heart disease (CHD). Although simvastatin is known to lower serum lipid concentrations, the protective effect of such lipid-lowering therapy against primary CHD has not been established in Japanese patients with hypercholesterolemia. The Japan Lipid Intervention Trial was a 6-year, nationwide cohort study of 47,294 patients treated with open-labeled simvastatin (5-10 mg/day) and monitored by physicians under standard clinical conditions. The aim of the study was to determine the relationship between the occurrence of CHD and the serum lipid concentrations during low-dose simvastatin treatment. Simvastatin reduced serum concentrations of total cholesterol (TC), low-density lipoprotein- cholesterol (LDL-C) and triglyceride (TG), by 18.4%, 26.8% and 16.1% on average, respectively, during the treatment period. The risk of coronary events was higher when the average TC concentration was ≥240 mg/dl and the average LDL-C concentration was ≥160mg/dl. The incidence of coronary events increased in the patients with TG concentration ≥300 mg/dl compared with patients with TG concentration <150 mg/dl. The high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of coronary events. The J-curve association was observed between average TC or LDL-C concentrations and total mortality. Malignancy was the most prevalent cause of death. The health of patients should be monitored closely when there is a remarkable decrease in TC and LDL-C concentrations with low-dose statin. A reasonable strategy to prevent coronary events in Japanese hypercholesterolemic patients without prior CHD under low-dose statin treatment might be regulating the serum lipid concentrations to at least <240 mg/dl for TC, <160 mg/dl for LDL-C, ≅300 mg/dl for TG, and >40 mg/dl for HDL-C., 金沢大学大学院医学系研究科},
 pages = {1087--1095},
 title = {Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia - Primary prevention cohort study of the Japan lipid intervention trial (J-LIT)},
 volume = {66},
 year = {2002}
}