{"created":"2023-07-27T06:28:30.812431+00:00","id":13104,"links":{},"metadata":{"_buckets":{"deposit":"1c3cc661-6719-4f2b-9a6f-18d5aeb6237b"},"_deposit":{"created_by":3,"id":"13104","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13104"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013104","sets":["1132:1133:1134"]},"author_link":["20768","20767","20770","20765","20763","20769","20764","20771","20766","389"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1095","bibliographicPageStart":"1087","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Circulation Journal"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperlipidemia is a well-established risk factor for primary coronary heart disease (CHD). Although simvastatin is known to lower serum lipid concentrations, the protective effect of such lipid-lowering therapy against primary CHD has not been established in Japanese patients with hypercholesterolemia. The Japan Lipid Intervention Trial was a 6-year, nationwide cohort study of 47,294 patients treated with open-labeled simvastatin (5-10 mg/day) and monitored by physicians under standard clinical conditions. The aim of the study was to determine the relationship between the occurrence of CHD and the serum lipid concentrations during low-dose simvastatin treatment. Simvastatin reduced serum concentrations of total cholesterol (TC), low-density lipoprotein- cholesterol (LDL-C) and triglyceride (TG), by 18.4%, 26.8% and 16.1% on average, respectively, during the treatment period. The risk of coronary events was higher when the average TC concentration was ≥240 mg/dl and the average LDL-C concentration was ≥160mg/dl. The incidence of coronary events increased in the patients with TG concentration ≥300 mg/dl compared with patients with TG concentration <150 mg/dl. The high-density lipoprotein cholesterol (HDL-C) inversely correlated with the risk of coronary events. The J-curve association was observed between average TC or LDL-C concentrations and total mortality. Malignancy was the most prevalent cause of death. The health of patients should be monitored closely when there is a remarkable decrease in TC and LDL-C concentrations with low-dose statin. A reasonable strategy to prevent coronary events in Japanese hypercholesterolemic patients without prior CHD under low-dose statin treatment might be regulating the serum lipid concentrations to at least <240 mg/dl for TC, <160 mg/dl for LDL-C, ≅300 mg/dl for TG, and >40 mg/dl for HDL-C.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/circj.66.1087","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/circj/66/12/66_1087/_article/-char/en","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11591968","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-9843","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuzaki, Masunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mabuchi, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsuzawa, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakaya, Noriaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oikawa, Shinichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimamoto, Kazuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itakura, Hiroshige"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MABUCHI-H-1087.pdf","filesize":[{"value":"205.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MABUCHI-H-1087.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13104/files/ME-PR-MABUCHI-H-1087.pdf"},"version_id":"1e748202-d54d-44f3-bc4e-3c6ed4c58b41"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia - Primary prevention cohort study of the Japan lipid intervention trial (J-LIT)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia - Primary prevention cohort study of the Japan lipid intervention trial (J-LIT)"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13104","relation_version_is_last":true,"title":["Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia - Primary prevention cohort study of the Japan lipid intervention trial (J-LIT)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:10:26.718020+00:00"}