@article{oai:kanazawa-u.repo.nii.ac.jp:00013159,
 author = {Miyati, Tosiaki and Mase, Mitsuhito and Kasai, Harumasa and Hara, Masaki and Yamada, Kazuo and Shibamoto, Yuta and Soellinger, Michaela and Baltes, Christof and Luechinger, Roger},
 issue = {2},
 journal = {Journal of Magnetic Resonance Imaging},
 month = {Aug},
 note = {Purpose: To assess the state and dynamics of the intracranial system in idiopathic normal-pressure hydrocephalus (I-NPH), we determined intracranial compliance using magnetic resonance imaging (MRI). Materials and Methods: The intracranial compliance index (ICCI), which was defined as the ratio of the peak-to-peak intracranial volume change (ICVCp-p) to the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p) during the cardiac cycle, was obtained from the net transcranial blood and CSF flow measured with phase-contrast (PC) cine MRI. ICCI was determined in patients with I-NPH (N = 7), brain atrophy, or asymptomatic ventricular dilation (VD) (N = 6), and in healthy volunteers (control group; N = 11). The changes in ICCI indices were also analyzed after a CSF tap test (N = 2). Results: The ICCI in the I-NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. The ICVC p-p was also lower than in the control and VD groups. However, no significant difference was found in the PGp-p between groups. The ICCI increased after the tap test. Conclusion: Intracranial compliance analysis with MRI makes it possible to noninvasively obtain more detailed information of intracranial biomechanics in the I-NPH and to assist in the diagnosis of I-NPH. © 2007 Wiley-Liss, Inc., 金沢大学大学院医学系研究科量子医療技術学},
 pages = {274--278},
 title = {Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus},
 volume = {26},
 year = {2007}
}