@article{oai:kanazawa-u.repo.nii.ac.jp:00013178,
 author = {Niwa, Hideki and Sasaki, Motoko and Haratake, Joji and Kasai, Takahiko and Katayanagi, Kazuyoshi and Kurumaya, Hiroshi and Matsuda, Shinji and Minato, Hiroshi and Zen, Yoh and Uchiyama, Akio and Miwa, Atsuo and Saito, Katsuhiko and Sudo, Yoshiko and Nakanuma, Yasuni},
 issue = {11},
 journal = {Hepatology Research},
 month = {Nov},
 note = {Aim: Serum antinuclear antibodies (ANA) are occasionally noted in patients with non-alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH. Methods: We compared clinicopathological features in patients with ANA-positive NASH (n = 35) and ANA-negative NASH (n = 36). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically. Results: ANA-positive NASH was significantly associated with female gender (P = 0.005), high degree of portal inflammation (P = 0.039), interface activity (P = 0.036) and hepatocellular ballooning (P = 0.0008). In addition, ANA of high titer (320-fold or more) was significantly associated with the histological grade and stage of NASH (P = 0.02). The degree of steatosis wais rather mild in the high-titer ANA group(P = 0.01). The analysis of inflammatory cell profiles revealed that CD3-positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA-positive and ANA-negative groups. There was no difference in the distribution of oxidative stress markers between ANA-positive and ANA-negative groups. Conclusion: These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis. © 2007 The Japan Society of Hepatology., 金沢大学大学院医学系研究科がん細胞学},
 pages = {923--931},
 title = {Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis},
 volume = {37},
 year = {2007}
}