{"created":"2023-07-27T06:28:35.092494+00:00","id":13178,"links":{},"metadata":{"_buckets":{"deposit":"106d997b-3bfc-4152-8b8a-91b7d8dae180"},"_deposit":{"created_by":3,"id":"13178","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13178"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013178","sets":["1132:1133:1134"]},"author_link":["21069","21072","21066","21068","20075","21065","21064","21067","21070","21063","129","887","92","21071"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"931","bibliographicPageStart":"923","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Hepatology Research"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: Serum antinuclear antibodies (ANA) are occasionally noted in patients with non-alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH. Methods: We compared clinicopathological features in patients with ANA-positive NASH (n = 35) and ANA-negative NASH (n = 36). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically. Results: ANA-positive NASH was significantly associated with female gender (P = 0.005), high degree of portal inflammation (P = 0.039), interface activity (P = 0.036) and hepatocellular ballooning (P = 0.0008). In addition, ANA of high titer (320-fold or more) was significantly associated with the histological grade and stage of NASH (P = 0.02). The degree of steatosis wais rather mild in the high-titer ANA group(P = 0.01). The analysis of inflammatory cell profiles revealed that CD3-positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA-positive and ANA-negative groups. There was no difference in the distribution of oxidative stress markers between ANA-positive and ANA-negative groups. Conclusion: These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis. © 2007 The Japan Society of Hepatology.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科がん細胞学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1872-034X.2007.00150.x","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11140867","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1386-6346","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Niwa, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Motoko"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Haratake, Joji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kasai, Takahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayanagi, Kazuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kurumaya, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Matsuda, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minato, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Zen, Yoh"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Uchiyama, Akio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miwa, Atsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Katsuhiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sudo, Yoshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanuma, Yasuni"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SASAKI-M-923.pdf","filesize":[{"value":"975.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SASAKI-M-923.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13178/files/ME-PR-SASAKI-M-923.pdf"},"version_id":"46ef53c7-d1e4-48f3-9d21-0d9ad9be4ac6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13178","relation_version_is_last":true,"title":["Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:09:36.813226+00:00"}