{"created":"2023-07-27T06:28:36.774683+00:00","id":13204,"links":{},"metadata":{"_buckets":{"deposit":"5284f321-3483-4034-b59c-2c9a89c83dfa"},"_deposit":{"created_by":3,"id":"13204","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13204"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013204","sets":["1132:1133:1134"]},"author_link":["21195","21188","21184","21187","21185","20194","21191","21193","255","21189","21186","21194","21190","21192"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"872","bibliographicPageStart":"865","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"Journal of Medical Virology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently increased availability of antiretroviral therapy (ART) has mitigated HIV-1/AIDS prognoses especially in resource poor settings. The emergence of ART resistance-associated mutations from non-suppressive ART has been implicated as a major cause of ART failure. Reverse transcriptase inhibitor (RTI)-resistance mutations among 12 non-subtype B HIV-1-infected children with treatment failure were evaluated by genotypically analyzing HIV-1 strains isolated from plasma obtained between 2001 and 2004. A region of pol-RT gene was amplified and at least five clones per sample were analyzed. Phylogenetic analysis revealed HIV-1 subtype A1 (n = 7), subtype C (n = 1), subtype D (n = 3), and CRF02_AG (n = 1). Before treatment, 4 of 12 (33.3%) children had primary RTI-resistance mutations, K103N (n = 3, ages 5-7 years) and Y181C (n = 1, age 1 year). In one child, K103N was found as a minor population (1/5 clones) before treatment and became major (7/7 clones) 8 months after RTI treatment. In 7 of 12 children, M184V appeared with one thymidine-analogue-associated mutation (TAM) as the first mutation, while the remaining 5 children had only TAMs appearing either individually (n = 2), or as TAMs 1 (M41L, L210W, and T215Y) and 2 (D67N, K70R, and K219Q/E/R) appearing together (n = 3). These results suggest that \"vertically transmitted\" primary RTI-resistance mutations, K103N and Y181C, can persist over the years even in the absence of drug pressure and impact RTI treatment negatively, and that appearing patterns of RTI-resistance mutations among non-subtype B HIV-1-infected children could possibly be different from those reported in subtype B-infected children. © 2007 Wiley-Liss, Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科感染症制御学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/jmv.20912","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00702400","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0146-6615","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lwembe, Raphael"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ochieng, Washingtone"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Panikulam, Annie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mongoina, Charles O."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Palakudy, Tresa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kageyama, Seiji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Naohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shioda, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Musoke, Rachel"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Owens, Mary"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Songok, Elijah M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okoth, Frederick A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichimura, Hiroshi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-ICIMURA-H-865.pdf","filesize":[{"value":"161.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-ICIMURA-H-865.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13204/files/ME-PR-ICIMURA-H-865.pdf"},"version_id":"b2b16cbe-0408-4801-88b2-a47b92d29e21"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-retroviral drug resistance-associated mutations among non-subtype B HIV-1-infected Kenyan children with treatment failure","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-retroviral drug resistance-associated mutations among non-subtype B HIV-1-infected Kenyan children with treatment failure"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13204","relation_version_is_last":true,"title":["Anti-retroviral drug resistance-associated mutations among non-subtype B HIV-1-infected Kenyan children with treatment failure"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T12:25:20.381190+00:00"}