@article{oai:kanazawa-u.repo.nii.ac.jp:00013209,
 author = {Hashimotodani, Yuki and Ohno-Shosaku, Takako and Kano, Masanobu},
 issue = {3},
 journal = {Current Opinion in Neurobiology},
 month = {Jun},
 note = {Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. They are released from postsynaptic neurons and cause transient and long-lasting reduction of neurotransmitter release through activation of presynaptic cannabinoid receptors. Endocannabinoid release is induced either by increased postsynaptic Ca2+ levels or by activation of Gq/11-coupled receptors. When these two stimuli coincide, endocannabinoid release is markedly enhanced, which is attributed to the Ca2+ dependency of phospholipase Cβ (PLCβ). This Ca2+-assisted receptor-driven endocannabinoid release is suggested to participate in various forms of synaptic plasticity, including short-term associative plasticity in the cerebellum and spike-timing-dependent long-term depression in the somatosensory cortex. In these forms of plasticity, PLCβ seems to function as a coincident detector of presynaptic and postsynaptic activities. © 2007 Elsevier Ltd. All rights reserved., 金沢大学大学院医学系研究科機能障害学},
 pages = {360--365},
 title = {Ca2+-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities},
 volume = {17},
 year = {2007}
}