{"created":"2023-07-27T06:28:37.421647+00:00","id":13214,"links":{},"metadata":{"_buckets":{"deposit":"0c189c93-611f-4c96-9aae-9efeefb76f99"},"_deposit":{"created_by":3,"id":"13214","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13214"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013214","sets":["1132:1133:1134"]},"author_link":["21219","21223","21222","21220","297","21221"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Cough"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inflammatory mediators are involved in the pathogenesis of airway inflammation, but the role of prostaglandin I2 (PGI2) remains obscure. This study was designed to investigate the role of PGI2 in cough reflex sensitivity of the asthmatic airway, which is characterized by chronic eosinophilic airway inflammation. The effect of beraprost, a chemically and biologically stable analogue of PGI2, on cough response to inhaled capsaicin was examined in 21 patients with stable asthma in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. The cough threshold was significantly (p < 0.05) decreased after two weeks of treatment with beraprost [17.8 (GSEM 1.20) μM] compared with placebo [30.3 (GSEM 1.21) μM]. PGI2 increases cough reflex sensitivity of the asthmatic airway, suggesting that inhibition of PGI2 may be a novel therapeutic option for patients with asthma, especially cough predominant asthma.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科機能再生学","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1745-9974-3-2","subitem_relation_type_select":"DOI"}}]},"item_4_relation_27":{"attribute_name":"シリーズ","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"2"}]}]},"item_4_rights_24":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://creativecommons.org/licenses/by/2.0/"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1745-9974","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishiura, Yoshihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimura, Masaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nobata, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oribe, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abo, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Myou, Shigeharu"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-FUJIMURA-M-2.pdf","filesize":[{"value":"367.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMURA-M-2.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13214/files/ME-PR-FUJIMURA-M-2.pdf"},"version_id":"ddd15c21-0945-42ac-89d0-4807aac56e30"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13214","relation_version_is_last":true,"title":["Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:09:14.008025+00:00"}