@article{oai:kanazawa-u.repo.nii.ac.jp:00013215,
 author = {Hara, Johsuke and Fujimura, Masaki and Myou, Shigeharu and Oribe, Yoshitaka and Furusho, Shiho and Kita, Toshiyuki and Katayama, Nobuyuki and Abo, Miki and Ohkura, Noriyuki and Herai, Yoriko and Hori, Akihiro and Ishiura, Yoshihisa and Nobata, Kouichi and Ogawa, Haruhiko and Yasui, Masahide and Kasahara, Kazuo and Nakao, Shinji},
 issue = {6},
 journal = {Cough},
 month = {Sep},
 note = {Background Late asthmatic response is observed following antigen challenge in actively, but not passively, sensitized guinea pigs. Although cough reflex sensitivity is increased after antigen challenge in actively sensitized guinea pigs, it is unknown whether the antigen-induced increase in cough reflex sensitivity develops in passively sensitized animals. The aim of this study was to compare the cough reflex sensitivity to inhaled capsaicin after an inhaled antigen challenge between actively and passively sensitized guinea pigs. Methods Measurement of number of coughs elicited by increasing concentrations of capsaicin (10-6 and 10-4 M) and bronchial responsiveness to ascending concentrations of methacholine, and analysis of bronchoalveolar lavage fluid (BALF) were separately performed 24 h after an antigen challenge in actively and passively sensitized guinea pigs. Results Percentage of eosinophils in BALF and bronchial responsiveness to methacholine were increased 24 h after the antigen challenge in both actively and passively sensitized animals compared with saline-challenged actively and passively sensitized animals, respectively. Absolute number of eosinophils in BALF from actively sensitized and antigen-challenged guinea pigs was significantly greater than that from passively sensitized and antigen-challenged animals. Cough response to capsaicin and concentration of substance P in BALF were increased 24 h after the antigen challenge in actively sensitized guinea pigs, but not in passively sensitized guinea pigs. Bronchial responsiveness, cough reflex sensitivity and substance P concentration and total cells in BALF were increased in actively sensitized and saline challenged guinea pigs compared with passively sensitized and saline challenged animals. Conclusion The results suggest that active sensitization per se increases cough reflex sensitivity accompanied by increased inflammatory cells and substance P level in BALF, and antigen challenge further increases them, while simple IgE- and/or IgG-mediated allergic reaction per se or the low intensity of eosinophil infiltration in the airway itself may not affect cough reflex sensitivity in guinea pigs., 金沢大学大学院医学系研究科機能再生学},
 pages = {1--8},
 title = {Comparison of cough reflex sensitivity after an inhaled antigen challenge between actively and passively sensitized guinea pigs},
 volume = {1},
 year = {2005}
}