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Antisense oligodeoxyribonucleotide targeting cAMP response element-binding protein inhibits growth of rat submandibular gland in vitro
http://hdl.handle.net/2297/6778
http://hdl.handle.net/2297/677824510b57-fa4a-48fb-879c-5def0ca8210d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA00508022-ISEKI-S-111.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Antisense oligodeoxyribonucleotide targeting cAMP response element-binding protein inhibits growth of rat submandibular gland in vitro | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
井関, 尚一
× 井関, 尚一 |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学大学院医学系研究科がん細胞学 | |||||
| 書誌情報 |
Acta Histochemica et Cytochemica 巻 34, 号 2, p. 111-117, 発行日 2001-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0044-5991 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508022 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1267/ahc.34.111 | |||||
| 出版者 | ||||||
| 出版者 | 日本組織細胞化学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The transcription factor, cyclic AMP response element-binding protein (CREB), occurs in the nuclei of acinar cells of the rat submandibular gland during the early postnatal periods. To elucidate the role of CREB in the growth of submandibular gland, the effect of an antisense oligodeoxyribonucleotide (ODN) targeting CREB was examined in the organ culture system of neonatal rat submandibular gland. In the presence of antisense-CREB ODN in the culture media for 48 hr, a significant decrease in the growth of cultured gland was observed in terms of both the area of acinar epithelial tissue and 3H-thymidine-labeling index of acinar cells, with concomitant decrease in the nuclear immunoreactivity for CREB without any degenerative changes in the histology of the gland. In contrast, sense-CREB ODN exhibited no effect on acinar growth. Administration of the β-adrenergic agonist isoproterenol (IPR) induced enhanced proliferation of acinar cells, which was also inhibited by antisense-CREB ODN. In contrast, the proliferation of connective tissue cells was neither enhanced by IPR nor inhibited by antisense-CREB ODN. These results suggest that the transcription factor CREB plays specific roles in the proliferation of submandibular gland acinar cells during the early postnatal periods. | |||||
| 権利 | ||||||
| 権利情報 | 日本組織細胞化学会の許諾を得て登録 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jstage.jst.go.jp/article/ahc/34/2/34_111/_article/-char/en | |||||
