{"created":"2023-07-27T06:28:42.211138+00:00","id":13288,"links":{},"metadata":{"_buckets":{"deposit":"652aba9f-f415-4117-9654-b7d717babf96"},"_deposit":{"created_by":3,"id":"13288","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13288"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013288","sets":["1132:1133:1134"]},"author_link":["21486","413","20075","21489","21484","21482","21487","62","21488","21485","225","92","21483"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-3","bibliographicVolumeNumber":"588","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Insulin resistance is a major pathological condition associated with obesity and metabolic syndrome. Insulin resistance and the renin-angiotensin system are intimately linked. We evaluated the role of the renin-angiotensin system in the pathogenesis of insulin resistance-associated, non-alcoholic steatohepatitis by using the angiotensin II type 1 receptor blocker olmesartan medoxomil in a diabetic rat model. The effects of olmesartan on methionine- and choline-deficient (MCD) diet-induced steatohepatitis were investigated in obese, diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and control Long-Evans Tokushima Otsuka (LETO) rats. Components of the renin-angiotensin system were up-regulated in the livers of OLETF rats, compared with LETO rats. In OLETF, but not LETO, rats, oral administration of olmesartan for 8 weeks ameliorated insulin resistance. Moreover, olmesartan suppressed MCD diet-induced hepatic steatosis and the hepatic expression of lipogenic genes (sterol regulatory element-binding protein-1c and fatty acid synthase) in OLETF, but not LETO, rats. In both OLETF and LETO rats, olmesartan inhibited hepatic oxidative stress (4-hydroxy-2-nonenal-modified protein) and expression of NADPH oxidase. Olmesartan also inhibited hepatic fibrosis, stellate cell activation, and expression of fibrogenic genes (transforming growth factor-β, α1 [I] procollagen, plasminogen activator inhibitor-1) in both OLETF and LETO rats. In conclusion, pharmacological blockade of the angiotensin II type 1 receptor slows the development of steatohepatitis in the OLETF rat model. This angiotensin II type 1 receptor blocker may exert insulin resistance-associated effects against hepatic steatosis and inflammation as well as direct effects against the generation of reactive oxygen species and fibrogenesis. © 2008 Elsevier B.V. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科","subitem_description_type":"Other"},{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejphar.2008.04.028","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639687","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-2999","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurita, Seiichiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takamura, Toshinari"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Matsuzawa-Nagata, Naoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uno, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nabemoto, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikura, Kazuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Misu, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ando, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zen, Yoh"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakanuma, Yasuni"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KURITA-S-316.pdf","filesize":[{"value":"610.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KURITA-S-316.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13288/files/ME-PR-KURITA-S-316.pdf"},"version_id":"b22b63a7-c512-4885-802e-08848122a9db"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13288","relation_version_is_last":true,"title":["Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:07:52.753960+00:00"}