{"created":"2023-07-27T06:28:42.667299+00:00","id":13295,"links":{},"metadata":{"_buckets":{"deposit":"5ac0ee36-6aa4-4a79-8ebf-dee0e0be322d"},"_deposit":{"created_by":3,"id":"13295","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13295"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013295","sets":["1132:1133:1134"]},"author_link":["21517","21525","21518","21519","21524","15392","21516","21520","21521","21526","21522","21523"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"2481","bibliographicPageStart":"2471","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Stress-induced analgesia (SIA) is a key component of the defensive behavioral \"fight-or-flight\" response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin/orexin (Hcrt) and nociceptin/orphanin FQ (N/OFQ) peptidergic systems in the regulation of SIA. Using immunohistochemistry in brain tissue from wild-type mice, we identified N/OFQ-containing fibers forming synaptic contacts with Hcrt neurons at both the light and electron microscopic levels. Patch clamp recordings in GFP-tagged mouse Hcrt neurons revealed that N/OFQ hyperpolarized, decreased input resistance, and blocked the firing of action potentials in Hcrt neurons. N/OFQ postsynaptic effects were consistent with opening of a G protein-regulated inwardly rectifying K+ (GIRK) channel. N/OFQ also modulated presynaptic release of GABA and glutamate onto Hcrt neurons in mouse hypothalamic slices. Orexin/ataxin-3 mice, in which the Hcrt neurons degenerate, did not exhibit SIA, although analgesia was induced by i.c.v. administration of Hcrt-1. N/OFQ blocked SIA in wild-type mice, while coadministration of Hcrt-1 overcame N/OFQ inhibition of SIA. These results establish what is, to our knowledge, a novel interaction between the N/OFQ and Hcrt systems in which the corticotropin-releasing factor and N/OFQ systems coordinately modulate the Hcrt neurons to regulate SIA.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JC135115","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xie, Xinmin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wisor, Jonathan P."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Crowder, Tara L."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"LeWinter, Robin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Khroyan, Taline V."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanaka, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Diano, Sabrina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horvath, Takeshi L."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Takeshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Toll, Lawrence"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kilduff, Thomas S."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SAKURAI-T-2417.pdf","filesize":[{"value":"712.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SAKURAI-T-2417.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13295/files/ME-PR-SAKURAI-T-2417.pdf"},"version_id":"cc683d13-04db-4998-bc58-da6e6fbd6932"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13295","relation_version_is_last":true,"title":["Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:07:43.541446+00:00"}