{"created":"2023-07-27T06:28:43.721332+00:00","id":13311,"links":{},"metadata":{"_buckets":{"deposit":"03b07897-d101-4bc4-b933-3c7dc27d6706"},"_deposit":{"created_by":3,"id":"13311","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13311"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013311","sets":["1132:1133:1134"]},"author_link":["21587","21592","21586","21590","21589","504","21593","21588","21591","118"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2342","bibliographicPageStart":"2330","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tubular damage following ischemic renal injury is often reversible, and tubular epithelial cell (TEC) proliferation is a hallmark of tubular repair. Macrophages have been implicated in tissue repair, and CSF-1, the principal macrophage growth factor, is expressed by TECs. We therefore tested the hypothesis that CSF-1 is central to tubular repair using an acute renal injury and repair model, ischemia/reperfusion (I/R). Mice injected with CSF-1 following I/R exhibited hastened healing, as evidenced by decreased tubular pathology, reduced fibrosis, and improved renal function. Notably, CSF-1 treatment increased TEC proliferation and reduced TEC apoptosis. Moreover, administration of a CSF-1 receptor-specific (CSF-1R-specific) antibody after I/R increased tubular pathology and fibrosis, suppressed TEC proliferation, and heightened TEC apoptosis. To determine the contribution of macrophages to CSF-1-dependent renal repair, we assessed the effect of CSF-1 on I/R in mice in which CD11b + cells were genetically ablated and determined that macrophages only partially accounted for CSF-1-dependent tubular repair. We found that TECs expressed the CSF-1R and that this receptor was upregulated and coexpressed with CSF-1 in TECs following renal injury in mice and humans. Furthermore, signaling via the CSF-1R stimulated proliferation and reduced apoptosis in human and mouse TECs. Taken together, these data suggest that CSF-1 mediates renal repair by both a macrophage-dependent mechanism and direct autocrine/paracrine action on TECs.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI39087","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Menke, Julia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Yasunori"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Rabacal, Whitney A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Basu, Ranu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yeung, Yee G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Humphreys, Benjamin D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Takashi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Schwarting, Andreas"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Stanley, E. Richard"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kelley, Vicki R."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-WADA-T-2330.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-2330.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13311/files/ME-PR-WADA-T-2330.pdf"},"version_id":"36f0fa3c-76f2-4e27-8f4f-79030aea898c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13311","relation_version_is_last":true,"title":["CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:07:26.121200+00:00"}