@article{oai:kanazawa-u.repo.nii.ac.jp:00013378,
 author = {小野, 絵理 and 宮地, 利明 and 大野, 直樹 and 笠井, 治昌 and 原, 真咲 and 芝本, 雄太 and 川野, 誠 and 朝日, 美幸},
 issue = {3},
 journal = {医用画像情報学会雑誌 = Japan Society of Imaging and Information Sciences in Medicine},
 month = {Jan},
 note = {We evaluated the R2* (iron content) and fat fraction of the liver tissue simultaneously using modulus and real multiple gradient-echo (MRM-GRE) sequence. On a 1.5-T MRI, modulus images of 7-9 gradient-echoes were obtained by MRM-GRE sequence at a time. A real part of the first echo image was also reconstructed to differentiate below and above the 50 percent fat fraction. The fat fraction and R2* were obtained from the parameters of a theoretically fitted formula with each echo signal. R2* and fat fraction were measured with MRM-GRE in the phantom and the liver in normal volunteers (n=6) and patients with fatty liver (n=4) . MRI-derived fat fraction of the phantom was in good agreement with the actual value, and R2* of the phantom showed a strongly positive correlation with the actual iron content. MRI-derived fat fraction in fatty liver was significantly higher than that in the normal volunteers. However, no significant difference in R2* was found between fatty liver and normal volunteers. These results show that the MRM-GRE enables to differentiate the causes of signal reduction whether increasing R2*or increasing fat fraction. The MRM-GRE method makes it possible to simply and accurately assess the fat content and the iron content., 金沢大学医薬保健研究域保健学系},
 pages = {64--67},
 title = {MRM-GRE法を用いた肝臓の鉄含有量および脂肪含有率の同時測定},
 volume = {26},
 year = {2009}
}