@article{oai:kanazawa-u.repo.nii.ac.jp:00013385, author = {Kato-Motozaki, Yuko and Koma, Kiyonobu and Takahashi, Kazuya and Ishida, Chiho and Ueda, Masami and Kusunoki, Susumu and Yamada, Masahito}, issue = {7}, journal = {Internal Medicine}, month = {Jan}, note = {Polyethylene glycol-interferon ホア (PEG-IFNホア) has been used as the standard treatment for hepatitis C virus (HCV) infection. There have been no previous reports of polyradiculoneuropathy with anti-ganglioside antibodies induced by PEG-IFNホア-2b. We report a 59-year-old man who developed polyradiculoneuropathy during treatment with PEG-IFN ホア-2b for chronic HCV infection. Serum levels of anti-asialo-GM1 (GA1) and anti-GM1 antibodies were elevated. Cessation of therapy with double filtration plasmapheresis resulted in marked improvement in his symptoms accompanied by a reduction in the antibody level. PEG-IFN ホア-2b may induce peripheral neuropathy mediated by anti-GA1 and anti-GM1 antibodies. © 2009 The Japanese Society of Internal Medicine., 金沢大学医薬保健研究域医学系}, pages = {569--572}, title = {Polyethylene Glycol Interferon α-2b-induced Immune-mediated Polyradiculoneuropathy}, volume = {48}, year = {2009} }