@article{oai:kanazawa-u.repo.nii.ac.jp:00013401,
 author = {Ueki, Koichiro and Okabe, Katsuhiko and Nakagawa, Kiyomasa and Yamamoto, Etsuhide},
 issue = {6},
 journal = {Clinical Oral Implants Research},
 month = {Jun},
 note = {Purpose: The purpose of this study was to histologically and immuno-histochemically evaluate tissue changes in the maxillary sinus after bone screw implantation and maxillary sinus augmentation using self-setting α-tricalcium phosphate (α-TCP; BIOPEX®-R) in rabbit. Study design: Adult male Japanese white rabbits (n=15, 12-16 weeks, 2.5-3kg) were used. The sinus lift was made from the nasal bone of a rabbit. Bone screws (Dual top auto-screw®) were implanted into the nasal bone, and after BIOPEX®-R was implanted into the left elevated space (operated side) an atelocollagen sponge (ACS: Teruplug®) was implanted into the right elevated space (control side). The rabbits were sacrificed at 4, 12 and 24 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immune-histochemical analysis, the specimens were treated with bone morphogenetic protein-2 (BMP-2) antibodies. Finally, these were evaluated microscopically. Results: Tight bonding without fibrous tissue continued between the bone screw and BIOPEX®-R, and the rigidity of the bone screw in the nasal bone was retained for 24 weeks in all cases. The area ofnew bone formation increased gradually on both sides; however, there was no significant difference between both sides at 4, 12 and 24 weeks. The number of BMP-2-stained cells on the experimental side was significantly larger than that on the control side after 4 weeks (P=0.0361). Conclusion: This study suggested the usefulness of self-setting α-TCP (BIOPEX®-R) to maintain the rigidity of implanted bone screws from an early period, and the result of BMP-2 expression suggested that BIOPEX®-R could have bone-conductive activity in the maxillary sinus augmentation. © 2010 John Wiley & Sons A/S., 金沢大学医薬保健研究域医学系},
 pages = {606--612},
 title = {Use of self-setting α-tricalcium phosphate for maxillary sinus augmentation in rabbit},
 volume = {22},
 year = {2011}
}