{"created":"2023-07-27T06:28:50.598903+00:00","id":13413,"links":{},"metadata":{"_buckets":{"deposit":"308cfc35-32a3-4fa5-86b3-0bae0e47c605"},"_deposit":{"created_by":3,"id":"13413","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13413"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013413","sets":["1132:1133:1134"]},"author_link":["21951","21954","490","21948","21949","21952","21956","21953","21950","21955","21947"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-02-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1748","bibliographicPageStart":"1741","bibliographicVolumeNumber":"113","bibliographic_titles":[{"bibliographic_title":"Blood"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal transloca-tion t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50-K and 250-K SNP-chips) using the new algorithm AsCNAR (allele-specific copy-number analysis using anonymous references). Copy-number-neutral loss of heterozygosity (CNN-LOH) was identified at chromosomes 10q (3 cases), 11p (3 cases), and 19q (1 case). Twenty-eight samples (60%) did not have an obvious alteration (normal-copy-number [NC] group). Nineteen samples (40%) showed either one or more genomic abnormalities: 8 samples (17%) had trisomy 8 either with or without an additional duplication, deletion, or CNN-LOH (+8 group); and 11 samples (23%) had genomic abnormalities without trisomy 8 (other abnormalities group). These chromosomal abnormalities were acquired somatic mutations. Interestingly, FLT3-ITD mutations (11/47 cases) occurred only in the group with no genomic alteration (NC group). Taken together, these results suggest that the pathway of development of APL differs in each group: FLT3-ITD, tri-somy 8, and other genomic changes. Here, we showed for the first time hidden abnormalities and novel disease-related genomic changes in t(15;17) APL. © 2009 by The American Society of Hematology.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society of Hematology"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1182/blood-2007-12-130260","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00567156","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-4971","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akagi, Tadayuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Shih, Lee-Yung"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Motohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamata, Norihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Go"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sanada, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Ryoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miller, Carl W."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Liang, Der-Cherng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Seishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koeffler, H.Phillip"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-AKAGI-T-1741.pdf","filesize":[{"value":"205.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-AKAGI-T-1741.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13413/files/ME-PR-AKAGI-T-1741.pdf"},"version_id":"dae823d1-7895-4647-b331-b9e0d7b5465e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13413","relation_version_is_last":true,"title":["Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:05:29.103899+00:00"}