{"created":"2023-07-27T06:28:51.036318+00:00","id":13423,"links":{},"metadata":{"_buckets":{"deposit":"9cdb2034-82ae-436a-aa9e-b55552d901cd"},"_deposit":{"created_by":3,"id":"13423","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13423"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013423","sets":["1132:1133:1134"]},"author_link":["21985","21980","21981","21990","21992","21996","21986","21982","21978","21989","15392","21987","21994","21984","21993","21988","21979","21995","21991","21983"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"777","bibliographicPageStart":"768","bibliographicVolumeNumber":"120","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Investigation"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously, we have demonstrated that the bone morphogenetic protein (BMP) antagonist uterine sensitization-associated gene-1 (USAG-1) negatively regulates the renoprotective action of BMP-7 in a mouse model of tubular injury during acute renal failure. Here, we investigated the role of USAG-1 in renal function in Col4a3 -/- mice, which model Alport syndrome. Ablation of Usag1 in Col4a3-/- mice led to substantial attenuation of disease progression, normalization of GBM ultrastructure, preservation of renal function, and extension of life span. Immunohistochemical analysis revealed that USAG-1 and BMP-7 colocalized in the macula densa in the distal tubules, lying in direct contact with glomerular mesangial cells. Furthermore, in cultured mesangial cells, BMP-7 attenuated and USAG-1 enhanced the expression of MMP-12, a protease that may contribute to GBM degradation. These data suggest that the pathogenetic role of USAG-1 in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Clinical Investigation"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1172/JCI39569","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asada, Misako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashi, Atsuko Y."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Jin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oguchi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Mayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Sachiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asada, Nariaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takase, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okuda, Tomohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawachi, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Economides, Aris N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Robertson, Elizabeth"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Takeshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Goldschmeding, Roel"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muso, Eri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukatsu, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kita, Toru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagita, Motoko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SAKURAI-T-768.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SAKURAI-T-768.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13423/files/ME-PR-SAKURAI-T-768.pdf"},"version_id":"992e5a03-7d66-4523-8f6c-4bf650af7050"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13423","relation_version_is_last":true,"title":["Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:05:22.175637+00:00"}