@article{oai:kanazawa-u.repo.nii.ac.jp:00013435,
 author = {Ozawa, Kentaro and Kondo, Toshikazu and Hori, Osamu and Kitao, Yasuko and Stern, David M. and Eisenmenger, Wolfgang and Ogawa, Satoshi and Ohshima, Tohru},
 issue = {1},
 journal = {Journal of Clinical Investigation},
 month = {Jan},
 note = {Expression of angiogenic factors such as VEGF under conditions of hypoxia or other kinds of cell stress contributes to neovascularization during wound healing. The inducible endoplasmic reticulum chaperone oxygen-regulated protein 150 (ORP150) is expressed in human wounds along with VEGF. Colocalization of these two molecules was observed in macrophages in the neovasculature, suggesting a role of ORP150 in the promotion of angiogenesis. Local administration of ORP150 sense adenovirus to wounds of diabetic mice, a treatment that efficiently targeted this gene product to the macrophages of wound beds, increased VEGF antigen in wounds and accelerated repair and neovascularization. In cultured human macrophages, inhibition of ORP150 expression caused retention of VEGF antigen within the endoplasmic reticulum (ER), while overexpression of ORP150 promoted the secretion of VEGF into hypoxic culture supernatants. Taken together, these data suggest an important role for ORP150 in the setting of impaired wound repair and identify a key, inducible chaperone-like molecule in the ER. This novel facet of the angiogenic response may be amenable to therapeutic manipulation., 金沢大学医薬保健研究域医学系},
 pages = {41--50},
 title = {Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport},
 volume = {108},
 year = {2001}
}