@article{oai:kanazawa-u.repo.nii.ac.jp:00013442,
 author = {Iwata, Yasunori and Furuichi, Kengo and Kitagawa, Kiyoki and Hara, Akinori and Okumura, Toshiya and Kokubo, Satoshi and Shimizu, Kazuaki and Sakai, Norihiko and Sagara, Akihiro and Kurokawa, Yukie and Ueha, Satoshi and Matsushima, Satoshi and Kaneko, Shuichi and Wada, Takashi},
 issue = {5},
 journal = {Clinical and Experimental Nephrology},
 month = {Oct},
 note = {Objective: Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-prone mice. Methods: MDSCs were analyzed by flow cytometric staining of CD11b+ GR-1+ in MRL-Faslpr mice. CD4+ T-cell proliferation assay was performed by coculture with CD11b+ GR-1+ splenocytes. The percentage of immunosuppressive cells was examined during disease progression. Expression of chemokine receptor on immunosuppressive cells was analyzed, and chemotaxis assay was performed. Results: CD11b+ GR-1low cells had a suppressive effect on CD4+ T-cell proliferation, which was restored by an arginase-1 inhibitor. CD11b+ GR-1low cells increased in percentage during disease progression in kidney and blood. The number of migrated CD11b+ GR-1low cells increased in the presence of monocyte chemoattractant protein-1/CCL2. Conclusion: We assessed the involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mice. These cells regulate immunological responses via CCL2/CCR2 signaling. The regulation of immunosuppressive monocytes may provide novel therapeutic strategy for organ damage in autoimmune diseases. © 2010 Japanese Society of Nephrology.., 金沢大学医薬保健研究域医学系},
 pages = {411--417},
 title = {Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse},
 volume = {14},
 year = {2010}
}