{"created":"2023-07-27T06:28:52.872047+00:00","id":13467,"links":{},"metadata":{"_buckets":{"deposit":"3098c3e6-5ad6-454e-824c-1dac9695ed2d"},"_deposit":{"created_by":3,"id":"13467","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13467"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013467","sets":["1132:1133:1134"]},"author_link":["22156","22160","22157","22155","622","22165","22162","68","22154","22158","310","22166","22161","22163","1196","22159","22001","22164"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1241","bibliographicPageStart":"1234","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Journal of Gastroenterology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We aimed to evaluate the efficacy of a new combination antiemetic therapy comprising aprepitant, granisetron, and dexamethasone in gastric cancer patients undergoing chemotherapy with cisplatin and S-1. Methods: Gastric cancer patients scheduled to receive their first course of chemotherapy with cisplatin (60 mg/m2) and S-1 (80 mg/m2) were treated with a new combination antiemetic therapy aprepitant, granisetron, and dexamethasone on day 1; aprepitant and dexamethasone on days 2 and 3; and dexamethasone on day 4. The patients reported vomiting, nausea, use of rescue therapy, and change in the amount of diet intake, and completed the Functional Living Index-Emesis (FLIE) questionnaire. The primary endpoint was complete response (CR; no emesis and use of no rescue antiemetics) during the overall study phase (0-120 h after cisplatin administration). The secondary endpoints included complete protection (CP; CR plus no significant nausea); change in the amount of diet intake; and the impact of chemotherapy-induced nausea and vomiting (CINV) on daily life during the overall, acute (0-24 h), and delayed (24-120 h) phases. Results: Fifty-three patients were included. CR was achieved in 88.7, 98.1, and 88.7 % of patients in the overall, acute, and delayed phases, respectively. The corresponding rates of CP were 67.9, 96.2, and 67.9 %. Approximately half of the patients had some degree of anorexia. FLIE results indicated that 79.5 % of patients reported \"minimal or no impact of CINV on daily life\". Conclusions: Addition of aprepitant to standard antiemetic therapy was effective in gastric cancer patients undergoing treatment with cisplatin and S-1. © 2013 Springer Japan.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Gastroenterology 日本消化器病学会 / Springer Verlag (Germany)"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00535-012-0746-1","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10988015","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0944-1174","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oyama, Katsunobu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Fushida, Sachio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kaji, Masahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeda, Toshiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinami, Shinichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hirono, Yasuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshimoto, Katsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yabushita, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirosawa, Hisashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takai, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Hironobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasui, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuneda, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukada, Tomoya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kinoshita, Jun"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Fujimura, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ohta, Tetsuo"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-OYAMA-K-1234.pdf","filesize":[{"value":"246.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-OYAMA-K-1234.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13467/files/ME-PR-OYAMA-K-1234.pdf"},"version_id":"fee8d74d-2613-467f-a70a-1b568cf670e2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aprepitant plus granisetron and dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aprepitant plus granisetron and dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13467","relation_version_is_last":true,"title":["Aprepitant plus granisetron and dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:04:27.159839+00:00"}