@article{oai:kanazawa-u.repo.nii.ac.jp:00013531, author = {北島, 信治 and 坂井, 宣彦 and 古市, 賢吾 and 原, 章規 and 北川, 清樹 and 全, 陽 and 中田, 光俊 and 金子, 周一 and 和田, 隆志 and Kitajima, Shinji and Sakai, Norihiko and Furuichi, Kengo and Tomokage, Miki and Hara, Akinori and Kitagawa, Kiyoki and Sawada-Kitamura, Seiko and Zen, Yoh and Nakada, Mitsutoshi and Kaneko, Shuichi and Wada, Takashi}, issue = {5}, journal = {Modern Rheumatology}, month = {Oct}, note = {We described a case of neurosarcoidosis with necrotizing sarcoid granulomatosis in a 22-year-old man. Contrast-enhanced brain computed tomography scan and magnetic resonance imaging showed intracerebral multiple nodular lesions. Noncaseating and partial necrotizing granulomas were detected in the specimen resected by neurosurgery. In addition, immunohistochemical examination revealed the expression of angiotensin-converting enzyme in necrotizing granuloma. Thus, these findings were consistent with neurosarcoidosis. Clinical and pathological presentation, immunological features, and treatment modalities of neurosarcoidosis are discussed. © 2010 Japan College of Rheumatology., This is the pre-peer reviewed version of the following article: [Full cite], which has been published in final form at [link to final article]., 金沢大学医薬保健研究域医学系}, pages = {506--510}, title = {A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme}, volume = {20}, year = {2010} }