@article{oai:kanazawa-u.repo.nii.ac.jp:00013540,
 author = {Noguchi-Shinohara, Moeko and Hamaguchi, Tsuyoshi and Nozaki, Ichiro and Sakai, Kenji and Yamada, Masahito},
 issue = {8},
 journal = {Journal of Neurology},
 month = {Aug},
 note = {Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n = 12), AD (n = 10) and RPD but no CJD (non-CJD-RPD; n = 9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n = 10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this. © 2011 Springer-Verlag.},
 pages = {1464--1468},
 title = {Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease},
 volume = {258},
 year = {2011}
}