{"created":"2023-07-27T06:28:56.010098+00:00","id":13540,"links":{},"metadata":{"_buckets":{"deposit":"e608dd1e-5d28-403c-96d5-0f37091bea20"},"_deposit":{"created_by":3,"id":"13540","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13540"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013540","sets":["1132:1133:1134"]},"author_link":["22436","501","22437","210","22438"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1468","bibliographicPageStart":"1464","bibliographicVolumeNumber":"258","bibliographic_titles":[{"bibliographic_title":"Journal of Neurology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n = 12), AD (n = 10) and RPD but no CJD (non-CJD-RPD; n = 9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n = 10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this. © 2011 Springer-Verlag.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer-Verlag"}]},"item_4_relation_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"BA27675464","subitem_relation_type_select":"NCID"}}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00415-011-5960-x","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0340-5354","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noguchi-Shinohara, Moeko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamaguchi, Tsuyoshi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Nozaki, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Masahito"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SHINOHARA-M-1464.pdf","filesize":[{"value":"189.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SHINOHARA-M-1464.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13540/files/ME-PR-SHINOHARA-M-1464.pdf"},"version_id":"ed535e71-2b97-4de0-b26e-86729f6ea5fb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13540","relation_version_is_last":true,"title":["Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:03:03.697563+00:00"}