@article{oai:kanazawa-u.repo.nii.ac.jp:00013551,
 author = {Matsushita, Takashi},
 issue = {5},
 journal = {日本臨床免疫学会会誌 = Japanese journal of clinical immunology},
 month = {Jan},
 note = {Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5+ B-1a cells, CD1d+ marginal zone B cells, and transitional 2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1dhiCD5 +CD19hi subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. Remarkably, regulatory B cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of regulatory B cell function is reviewed in the context of previous studies that have identified and characterized regulatory B cells. © 2010 The Japan Society for Clinical Immunology. 近年，免疫応答におけるIL-10を産生する制御性B細胞の重要性が明らかにされてきた．しかしながら，制御性B細胞の分画の報告としてはB1a細胞（CD5+），Marginal zone B細胞（CD1dhiCD21hi），T2-marginal zone precursor B細胞（CD1dhiCD21hiCD23+IgM+）など統一した見解がなかったが，CD1dhiCD5+CD19hiの表現形であることが明らかとなった．特に，制御性B細胞の研究は自己免疫性疾患モデルマウスを使用した研究で，多くのことが解明されてきた．今回，自己免疫性疾患における制御性B細胞の研究でこれまで解っている知見をまとめ，その機能，治療への応用の可能性につき概説する.},
 pages = {234--241},
 title = {制御性B細胞と自己免疫性疾患},
 volume = {33},
 year = {2010}
}