{"created":"2023-07-27T06:28:56.479569+00:00","id":13551,"links":{},"metadata":{"_buckets":{"deposit":"202c1e60-65f1-47fd-8da8-c4e61e0a124a"},"_deposit":{"created_by":3,"id":"13551","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13551"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013551","sets":["1132:1133:1134"]},"author_link":["20219"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"241","bibliographicPageStart":"234","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"日本臨床免疫学会会誌 = Japanese journal of clinical immunology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5+ B-1a cells, CD1d+ marginal zone B cells, and transitional 2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1dhiCD5 +CD19hi subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. Remarkably, regulatory B cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of regulatory B cell function is reviewed in the context of previous studies that have identified and characterized regulatory B cells. © 2010 The Japan Society for Clinical Immunology. 近年，免疫応答におけるIL-10を産生する制御性B細胞の重要性が明らかにされてきた．しかしながら，制御性B細胞の分画の報告としてはB1a細胞（CD5+），Marginal zone B細胞（CD1dhiCD21hi），T2-marginal zone precursor B細胞（CD1dhiCD21hiCD23+IgM+）など統一した見解がなかったが，CD1dhiCD5+CD19hiの表現形であることが明らかとなった．特に，制御性B細胞の研究は自己免疫性疾患モデルマウスを使用した研究で，多くのことが解明されてきた．今回，自己免疫性疾患における制御性B細胞の研究でこれまで解っている知見をまとめ，その機能，治療への応用の可能性につき概説する.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Society for Clinical Immunology = 日本臨床免疫学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2177/jsci.33.234","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/jsci/33.234","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2010 日本臨床免疫学会 / The Japan Society for Clinical Immunology"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00357971","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0911-4300","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsushita, Takashi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MATSUSHITA-T-234.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUSHITA-T-234.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13551/files/ME-PR-MATSUSHITA-T-234.pdf"},"version_id":"f676df05-305f-449e-982c-39a0327f02a0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"制御性B細胞と自己免疫性疾患","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"制御性B細胞と自己免疫性疾患"},{"subitem_title":"Regulatory B cell and autoimmune disease","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13551","relation_version_is_last":true,"title":["制御性B細胞と自己免疫性疾患"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:02:50.238726+00:00"}