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Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding
http://hdl.handle.net/2297/29610
http://hdl.handle.net/2297/2961018d39bbb-220b-47bd-8024-c663b019d630
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-MIEDA-M-15391.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Mieda, Michihiro
× Mieda, Michihiro× Sakurai, Takeshi |
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| 書誌情報 |
Journal of Neuroscience 巻 31, 号 43, p. 15391-15396, 発行日 2011-10-26 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620404 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1523/JNEUROSCI.2801-11.2011 | |||||
| 出版者 | ||||||
| 出版者 | Society for Neuroscience | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Temporal restriction of feeding can entrain circadian behavioral and physiological rhythms in mammals. These changes in biological rhythms are postulated to be brought about by a putative food-entrainable oscillator (FEO) that is independent of the suprachiasmatic nucleus (SCN). However, the anatomical substrates and molecular machinery of FEO remain elusive. We report here that mice with a nervous system-specific deletion of Bmal1, an essential clock component, had a marked deficit in entrainment of locomotor activity by periodic feeding, accompanied by reduced food intake and subsequent loss of body weight. These mice exhibited a nearly normal light-entrainable activity rhythm driven by the SCN, because deletion of the Bmal1 gene in the SCN was only partial. These findings suggest that an SCN-independent FEO in the nervous system requires Bmal1 and plays a critical role in adaptation of circadian locomotor activity and food intake to periodic feeding. © 2011 the authors. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jneurosci.org/content/31/43/15391 | |||||
