{"created":"2023-07-27T06:29:00.361537+00:00","id":13644,"links":{},"metadata":{"_buckets":{"deposit":"4c66b6b2-49c0-49f2-965e-1e5575d256e5"},"_deposit":{"created_by":3,"id":"13644","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13644"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013644","sets":["1132:1133:1134"]},"author_link":["22753","22755","413","22754","62","22756","585","520","225"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e34952","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. Methodology/Principal Findings: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. Conclusions/Significance: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes. © 2012 Misu et al.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLoS ONE"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0034952","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Misu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Misu, Hirofumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ishikura, Kazuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurita, Seiichiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takeshita, Yumie"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Saito, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Takamura, Toshinari"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MISU-H-34952.pdf","filesize":[{"value":"244.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MISU-H-34952.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13644/files/ME-PR-MISU-H-34952.pdf"},"version_id":"6a9e9df6-a054-4b63-b37a-b48e0336e605"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13644","relation_version_is_last":true,"title":["Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:01:00.677361+00:00"}