{"created":"2023-07-27T06:29:00.913768+00:00","id":13657,"links":{},"metadata":{"_buckets":{"deposit":"4035b8b5-243b-49c8-b661-5d505f3575aa"},"_deposit":{"created_by":3,"id":"13657","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13657"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013657","sets":["1132:1133:1134"]},"author_link":["384"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"952","bibliographicPageStart":"947","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"日本眼科學会雜誌 = Journal of Japanese Ophthalmological Society"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年, 波長670nmのダイオードレーザーを光源とする角膜専用生体レーザー共焦点顕微鏡（HRT IIロストック角膜モジュール, ハイデルベルグ社, ドイツ）が開発され, 解像度の高い生体角膜前額断画像が得られるようになった. 本装置を用いて詳細なBowman層近傍の解析を行ったところ, Bowman層・実質境界面のレベルに存在する網状・線維状構造物を初めて確認した（K-structureと命名）. 本総説論文では, この構造物の生体レーザー共焦点顕微鏡所見について紹介し, 過去の組織学的報告との対応を試みた. また, モジュール先端部を用いて角膜に軽く圧迫を加えながら観察した際に, 本構造物に一致した隆起が角膜上皮基底層のレベルに形成されることを見出した. これらの所見から, 本構造物は角膜実質コラーゲン線維終末部の前額断面の所見であると推測し, 角膜（フルオレセイン）モザイク発生の解剖学的原因であるとの仮説を提唱した. Recently, cornea-specific in vivo laser confocal microscopy （Heidelberg Retina Tomograph 2 Rostock Cornea Module （HRT2-RCM）, Heidelberg Engineering GmbH, Dossenheim, Germany） has become available, are now possible detailed in vivo observation of corneal and conjunctival microstructure. Using HRT2-RCM, we have demonstrated the presence of “polymorphic structures composed of fibrillar material” beneath Bowman's layer in normal volunteer eyes. We surmise that these microstructures may correspond to the modified and condensed anterior stromal collagen fibers/lamellae that merge into Bowman's layer. We also observed numerous ridges protruding into the epithelial basal and wing cell layers after application of pressure with a Tomocap(R). These ridges corresponded exactly to the orientation of the K-structures beneath the epithelial cells, suggesting that these ridge formations correspond to the pattern of the anterior mosaic formation. The potential association of these microstructures with anterior corneal mosaic formation is also discussed in this review.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本眼科学会 = Japanese Ophthalmological Society"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nichigan.or.jp/member/journal/nggz/index.jsp","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/10023974916/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Japanese Ophthalmological Society"}]},"item_4_rights_24":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://www.nichigan.or.jp/index.jsp"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00187157","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0029-0203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 顕"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KOBAYASHI-A-947.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KOBAYASHI-A-947.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13657/files/ME-PR-KOBAYASHI-A-947.pdf"},"version_id":"9382bca4-ed73-4ae6-a423-9dc704568af2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生体レーザー共焦点顕微鏡を用いた Bowman 層・実質境界面の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体レーザー共焦点顕微鏡を用いた Bowman 層・実質境界面の解析"},{"subitem_title":"In Vivo Laser Confocal Microscopic Analysis of the Interface between Bowman's Layer and the Stroma of the Cornea","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13657","relation_version_is_last":true,"title":["生体レーザー共焦点顕微鏡を用いた Bowman 層・実質境界面の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:00:47.272523+00:00"}