@article{oai:kanazawa-u.repo.nii.ac.jp:00013667,
 author = {林, 裕 and 中田, 光俊 and 濱田, 潤一郎 and Hayashi, Yutaka and Nakada, Mitsutoshi and Konoshita, Masashi and Hamada, Jun-ichiro},
 issue = {7},
 journal = {Neurologia medico-chirurgica = 神経外科},
 month = {Jun},
 note = {Nonenhancing intrinsic brain tumors have been empirically treated with a strategy that has been adopted for World Health Organization (WHO) grade II gliomas (low-grade gliomas: LGGs), even though small parts of the tumors might have been diagnosed as WHO grade III gliomas after surgery. However, the best surgical strategy for nonenhancing gliomas, including LGGs, is still debatable. LGGs have the following features: slow growth, high possibility of histologically malignant transformation, and no clear border between the tumor and adjacent normal brain. We retrospectively examined 26 consecutive patients with nonenhancing gliomas who were surgically treated at Kanazawa University Hospital between January 2006 and May 2012, with special reference to functional reorganization, extent of resection (EOR), and functional mapping during awake surgery. These categories are closely related with the features of LGG, i.e. functional reorganization due to slow-growing nature, EOR with related malignant transformation, and functional mapping for delineating the unclear tumor border. Finally, we discuss surgical strategies for slow-growing gliomas that are represented by LGGs and nonenhancing gliomas. In conclusion, slow-growing gliomas tend to undergo functional reorganization, and the functional reorganization affects the presurgical evaluation for resectability based on tumor location related to eloquence. In the clinical setting, to definitely identify the reorganized functional regions, awake surgery is recommended. Therefore, awake surgery could increase the extent of the resection of the tumor without deficits, resulting in the delay of malignant transformation and increase in overall survival.},
 pages = {438--446},
 title = {Surgical strategies for nonenhancing slow-growing gliomas with special reference to functional reorganization: Review with own experience},
 volume = {53},
 year = {2013}
}