{"created":"2023-07-27T06:29:01.812956+00:00","id":13678,"links":{},"metadata":{"_buckets":{"deposit":"4abd6323-a403-48e7-909f-59413048ec90"},"_deposit":{"created_by":3,"id":"13678","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13678"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013678","sets":["1132:1133:1134"]},"author_link":["22866","22867","21219","21179","297"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"7","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Cough"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation.Methods: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.Results: The cough threshold was significantly (p < 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) μM].Conclusions: These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome. © 2010 Ishiura et al; licensee BioMed Central Ltd.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1471-213X-10-84","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.coughjournal.com/content/6/1/7","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 Ishiura et al; licensee BioMed Central Ltd."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1745-9974","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishiura, Yoshihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimura, Masaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohkura, Noriyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Myou, Shigeharu"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-FUJIMURA-M-7.pdf","filesize":[{"value":"214.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMURA-M-7.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13678/files/ME-PR-FUJIMURA-M-7.pdf"},"version_id":"a9b62cd9-ecb5-4885-a1be-86149ac8b0c5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13678","relation_version_is_last":true,"title":["Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T01:00:26.351778+00:00"}