{"created":"2023-07-27T06:29:06.600219+00:00","id":13791,"links":{},"metadata":{"_buckets":{"deposit":"86219384-679f-4251-b679-75820158c42c"},"_deposit":{"created_by":3,"id":"13791","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13791"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013791","sets":["1132:1133:1134"]},"author_link":["23192","23190","21777","594","23189","62","567","736","23191"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"294","bibliographicPageStart":"287","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Hypertension Research"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aldosterone is implicated in the pathogenesis of several cardiovascular diseases, including ischemia reperfusion (I/R) and myocardial infarction, and also causes oxidative stress and inflammation in cardiovascular systems. Benidipine, a long-acting T-and L-type calcium channel blocker, reduces infarct size following myocardial I/R in rabbits. Benidipine also inhibits the production of aldosterone in vitro. However, the precise mechanism of this phenomenon in vivo remains unknown. We therefore evaluated whether benedipine has a beneficial role through the regulation of oxidative stress in myocardial I/R. C57BL/6J mice were subjected to 30 min of left ascending coronary I/R. Benidipine was administered orally at 3 mg kg -1daily for 3 weeks without any changes in hemodynamic variables. Benidipine significantly reduced infarction size (13.4±2.5%) compared with controls (25.5±3.6%). Urinary 8-hydroxy-2′ deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, increased significantly after I/R. I/R induced increases in 8-OHdG were significantly lower with benidipine. Local myocardial 8-OHdG was also elevated in I/R, but this augmentation was significantly suppressed with benidipine. The plasma aldosterone concentration (PAC) significantly increased 2 days after I/R and remained elevated at least 7 days after I/R. Treatment with benidipine significantly decreased I/R-induced elevation of the PAC. I/R-induced markers of fibrosis in hearts also reduced in benidipine. These results suggest that the administration of benidipine reduces myocardial infarct size as well as systemic oxidative stress after I/R. These phenomena are partially linked to reduced plasma aldosterone levels. © 2012 The Japanese Society of Hypertension All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Hypertension 日本高血圧学会 / Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/hr.2011.183","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jpnsh.org/","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10847079","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-9636","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohtani, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Soichiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Takashima, Shin-ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitano, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okajima, Masaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Furusho, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Takamura, Masayuki"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KANEKO-S-287.pdf","filesize":[{"value":"790.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KANEKO-S-287.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13791/files/ME-PR-KANEKO-S-287.pdf"},"version_id":"2a7f313d-1aec-46d4-9d26-428d1534885a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13791","relation_version_is_last":true,"title":["Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:58:35.870759+00:00"}