{"created":"2023-07-27T06:29:08.021505+00:00","id":13825,"links":{},"metadata":{"_buckets":{"deposit":"22787ce7-4750-4eeb-8562-bd6be8ed1b76"},"_deposit":{"created_by":3,"id":"13825","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13825"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013825","sets":["1132:1133:1134"]},"author_link":["23277","23281","23282","249","23280","23278","23283","23279"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"536","bibliographicPageStart":"530","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"日本消化器外科学会雑誌 = The Japanese journal of gastroenterological surgery"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A 46-year-old man was admitted with dizziness and abdominal pain. Laboratory tests showed severe anemia. Computed tomography (CT) scan showed a large heterogeneous mass and fluid collection in the abdominal cavity. Under a diagnosis of intra-abdominal hemorrhage from the intra-abdominal mass, we performed an emergency operation. Laparotomy revealed a 12 x 10 x 6 cm solid tumor of the ileum with bleeding at about 150 cm distant from the ligament of Treitz, accompanied by peritoneal metastases. Partial resection of the ileum and coagulation of peritoneal metastases by electric knife were performed. Pathological examination showed interlaced bundles of large bizarre spindle-like tumor cells, high cellu-larity and 12 mitoses per 50 high-power fields. Immunohistochemical staining showed positive responses for c-kit and CD34, but negative responses for a-smooth muscle actin (SMA) and S-100 protein. Based on the above findings, the tumor was diagnosed as a high risk malignant gastrointestinal stromal tumor (GIST) of the small intestine. C-kit mutation analysis showed tumor had mutation at exon 11 of the c-kit gene. His postoperative course was uneventful. On the 14th postoperative day, oral administration of imatinib mesylate at 400 mg/day was started. The patient has been followed up for 5 years with no evidence of recurrence. © 2012 The Japanese Society of Gastroenterological Surgery. 症例は46歳の男性で，腹痛とふらつきを主訴に来院した．腹部は膨満し，下腹部に手拳大の腫瘤を触知した．腹部USおよび腹部CTで腹腔内に大量の液体貯留と腫瘤を認めた．腹水穿刺で血液を吸引したため腫瘤からの腹腔内出血と診断し，緊急手術を施行した．腫瘍は小腸間膜に存在し，表面から出血していた．また，腸間膜に多数の播種を認めた．腫瘍を含めて小腸を切除し，播種は電気メスで焼灼した．標本は12×10×6cmの充実性腫瘍で，割面は白色分葉状で一部に出血を認めた．免疫染色検査では腫瘍細胞はc-kit，CD34が陽性でα-smooth muscle actin（SMA），S-100は陰性であり，小腸のgastrointestinal stromal tumor（GIST）と診断した．術後早期よりimatinib mesylate 400mg/日の内服を継続し，術後5年の現在，無再発生存中である．","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本消化器外科学会 = Japanese Society of Gastroenterological Surger"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5833/jjgs.45.530","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsgs.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/jjgs/45/5/45_45.530/_article/-char/ja/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/DN/JST.JSTAGE/jjgs/45.530","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2012 一般社団法人　日本消化器外科学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00192066","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-9768","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 俊久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤井, 利次"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸川, 保"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石田, 誠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上田, 順彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤, 敏治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 明夫"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐藤, 保則"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-SATO-Y-530.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-SATO-Y-530.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13825/files/ME-PR-SATO-Y-530.pdf"},"version_id":"b11f5857-a799-45cc-b267-e57954238dcd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"術後のImatinib mesylate投与が有効と考えられた，腹膜播種を伴う小腸GISTの1切除症例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"術後のImatinib mesylate投与が有効と考えられた，腹膜播種を伴う小腸GISTの1切除症例"},{"subitem_title":"A case of gastrointestinal stromal tumor of the small intestine with peritoneal metastasis successfully treated with imatinib mesylate","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13825","relation_version_is_last":true,"title":["術後のImatinib mesylate投与が有効と考えられた，腹膜播種を伴う小腸GISTの1切除症例"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:58:02.965483+00:00"}