@article{oai:kanazawa-u.repo.nii.ac.jp:00013853, author = {Hara, Akinori and Wada, Takashi and Kitajima, Shinji and Toyama, Tadashi and Okumura, Toshiya and Kitagawa, Kiyoki and Iwata, Yasunori and Sakai, Norihiko and Furuichi, Kengo and Higuchi, Masato and Kaneko, Shuichi}, issue = {9}, journal = {American Journal of Hematology}, month = {Sep}, note = {A 42-year-old woman with systemic lupus erythematosus was admitted to our hospital because of severe anemia. Her bone marrow was almost normocellular and erythroblasts were nearly absent. Laboratory data showed elevated levels of lactate dehydrogenase and positive findings on Coombs' tests. On the basis of these findings, her anemia was diagnosed as the overlap of pure red cell aplasia with autoimmune hemolytic anemia. Radioimmunoprecipitation assay revealed that her serum was positive for anti-erythropoietin antibodies before therapy. Furthermore, the autoantibodies inhibited proliferation of an erythropoietin-dependent cell line in a dose-dependent manner. Immunosuppressive treatment improved the anemia accompanied with disappearance of the autoantibodies. © 2008 Wiley-Liss, Inc., 金沢大学医薬保健研究域医学系}, pages = {750--752}, title = {Combined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies}, volume = {83}, year = {2008} }