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Novel method for quantitative evaluation of cardiac amyloidosis using 201TlCl and 99mTc-PYP SPECT
http://hdl.handle.net/2297/32996
http://hdl.handle.net/2297/3299668bcdaf1-da69-42a5-9afd-0ed085e6fba9
| 名前 / ファイル | ライセンス | アクション |
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ME-PR-ONOGUCHI-M-634.pdf (786.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Novel method for quantitative evaluation of cardiac amyloidosis using 201TlCl and 99mTc-PYP SPECT | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamamoto, Yasushi
× Yamamoto, Yasushi× Onoguchi, Masahisa× Haramoto, Masuo× Kodani, Nobuhiro× Komatsu, Akio× Kitagaki, Hajime× Tanabe, Kazuaki |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 26, 号 8, p. 634-643, 発行日 2012-10-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10708017 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-012-0627-y | |||||
| 出版者 | ||||||
| 出版者 | 日本核医学会 Japanese Society of Nuclear Medicine / Springer Verlag (Germany) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective The degree of myocardial technetium- 99m- pyrophosphate ( 99mTc-PYP) accumulation in cardiac amyloidosis is conventionally evaluated by the PYP score. This method involves qualitative visual evaluation on twodimensional images. Here, we performed three-dimensional quantitative analysis using software developed in our laboratory. Methods We performed dual myocardial imaging using thallium- 201-chloride ( 201Tl-Cl) and 99mTc-PYP in cases of suspected cardiac amyloidosis and calculated the PYP accumulation rates of all myocardial pixels showing 99mTc- PYP accumulation. We defined this procedure as quantitative evaluation of the degree of 99mTc-PYP accumulation in the myocardium. Patients were divided into two groups with and without a diagnosis of cardiac amyloidosis, and we examined the PYP accumulation rates in both groups. In addition, we examined the PYP scores of the two groups by conventional qualitative evaluation. Results The PYP scores of the cardiac amyloidosis group were significantly higher than those of the other group. The PYP accumulation rates of the cardiac amyloidosis group were significantly higher than those of the other group. There were significant differences in the PYP accumulation rate and PYP score between the two groups. There was considered to be a threshold between the two groups in the case of the PYP accumulation rate. Conclusions When the threshold of the PYP score was defined as 3+ and that of the PYP accumulation rate as 41.5 %, the sensitivity of the PYP score and PYP accumulation rate was 84.6 %. However, the specificity of the PYP accumulation rate was higher than that of the PYP score. Quantitative evaluation by the PYP accumulation rate of the degree of 99mTc-PYP accumulation in the myocardium may be useful in the diagnosis of cardiac amyloidosis. © The Japanese Society of Nuclear Medicine 2012. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
