@article{oai:kanazawa-u.repo.nii.ac.jp:00013872,
 author = {Izumi, Kouji and Chang, Chawnshang},
 issue = {12},
 journal = {OncoImmunology},
 month = {Oct},
 note = {Inflammatory cytokines and chemokines released by macrophages in the prostate cancer microenvironment may signal via the androgen receptor (AR ) to influence tumor progression. In particular, macrophages appear to promote tumorigenesis by altering the chemokine (C-C motif) ligand 4 (CCL4)/AR signaling axis. This process can be blocked by AS C-J9®, an enhancer of AR degradation. AS C-J9® also inhibits the CCL2-dependent, signal transducer and activator of transcription 3 (STAT3)-mediated pro-metastatic signaling cascade that is generally activated by androgen deprivation therapy. Thus, targeting inflammatory cytokines signaling via the AR , with AS C-J9®, represents a promising therapeutic approach against prostate cancer progression. © 2013 Landes Bioscience.},
 pages = {1--3},
 title = {Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression},
 volume = {2},
 year = {2013}
}