@article{oai:kanazawa-u.repo.nii.ac.jp:00013921,
 author = {Kato, Hiroki and Tomita, Shigeyuki and Yamaguchi, Shoujiro and Ohtake, Hiroshi and Watanabe, Go},
 issue = {5},
 journal = {Transplantation},
 month = {Sep},
 note = {BACKGROUND: A new supercooling system using a variable magnetic field has been recently developed. Subzero nonfreezing preservation has been believed to be a beneficial method because of the lower metabolic rate. The purpose of this study was to evaluate the hemodynamic and metabolic effects of rat heart preservation in a variable magnetic field without cryoprotectants. METHODS: Rat hearts were perfused ex vivo for 120 min after 24-hr preservation in two groups (n=6 each): (1) conventional storage group, in which the hearts were stored at 4°C, and (2) the subzero group, in which the hearts were preserved at-3°C in a variable magnetic field. RESULTS: Reperfusion cardiac performance after preservation was significantly preserved in the subzero group compared with the conventional group with respect to heart rate, coronary flow, the peak positive dP/dt, and the peak negative dP/dt (P<0.05). Edema after reperfusion was significantly decreased (P<0.05), and the adenosine triphosphate level was higher in the subzero group (P<0.05). CONCLUSIONS: The rat hearts preserved in a variable magnetic field at-3°C showed better hemodynamic and metabolic performance than those preserved using conventional storage at 4°C. Copyright © 2012 Lippincott Williams &Wilkins.},
 pages = {473--477},
 title = {Subzero 24-hr nonfreezing rat heart preservation: A novel preservation method in a variable magnetic field},
 volume = {94},
 year = {2012}
}