{"created":"2023-07-27T06:29:12.308111+00:00","id":13924,"links":{},"metadata":{"_buckets":{"deposit":"7ba147be-d58e-4f7c-b4e0-ab3340d6da7b"},"_deposit":{"created_by":3,"id":"13924","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13924"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00013924","sets":["1132:1133:1134"]},"author_link":["23551","23552","376","23553","10713","22689"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"547","bibliographicPageStart":"543","bibliographicVolumeNumber":"96","bibliographic_titles":[{"bibliographic_title":"Annals of Thoracic Surgery"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The internal thoracic artery (ITA) is a very useful conduit for coronary artery bypass artery (CABG), with excellent long-term patency. With the purpose to dilate the ITA graft and increase graft free flow (GFF) intraoperatively, we evaluated the usefulness of intraluminal injection of fasudil, a Rho-kinase inhibitor, in comparison to the conventional graft dilating agent, papaverine. Methods: Between June 2011 and January 2012, 30 patients with ischemic heart disease who underwent isolated CABG using ITA were enrolled. The patients were randomly assigned to 2 groups: the fasudil group (n = 15) in which fasudil solution 0.9 mg/dL was injected into the ITA, and the papaverine group (n = 15) in which papaverine solution (0.4 mg/mL) mixed with heparinized blood was used. Outcome measures were left ITA GFF, heart rate, and mean blood pressure during flow measurements, and histopathologic examination of the ITA. Results: In the fasudil group, GFF increased significantly (p < 0.01) from 19.7 ± 15.2 mL/minute at baseline to 66.9 ± 31.7 mL/minute after fasudil injection. In the papaverine group, GFF increased significantly (p < 0.01) from 22.9 ± 17.3 mL/minute at baseline to 44.8 ± 26.7 mL/minute after papaverine injection. Blood pressure and heart rate did not change significantly after drug injection in both groups. The GFF was significantly higher (p = 0.038) in fasudil-treated ITA than in papaverine-treated ITA. Histopathologically, the diameter of the ITA was markedly increased after fasudil injection. Elastica van Gieson staining showed that the multiple elastic lamellae structure was intact. Conclusions: Fasudil exhibited very potent vasodilatory effect on the ITA compared with conventional papaverine resulting in increased GFF. This agent is a useful graft dilating agent. © 2013 The Society of Thoracic Surgeons.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.athoracsur.2013.04.039","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00034975","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00533201","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0003-4975","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Go"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Noda, Yukihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Shigeyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Shojiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kiuchi, Ryuta"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-WATANABE-G-543.pdf","filesize":[{"value":"324.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-WATANABE-G-543.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/13924/files/ME-PR-WATANABE-G-543.pdf"},"version_id":"0d4e8541-1dd7-4ab5-af1f-5c9c21ca0434"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Fasudil is a superior vasodilator for the internal thoracic artery in coronary surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fasudil is a superior vasodilator for the internal thoracic artery in coronary surgery"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"13924","relation_version_is_last":true,"title":["Fasudil is a superior vasodilator for the internal thoracic artery in coronary surgery"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:56:06.953306+00:00"}