@article{oai:kanazawa-u.repo.nii.ac.jp:00013989,
 author = {Wada, Taizo and Muraoka, Masahiro and Yokoyama, Tadafumi and Toma, Tomoko and Kanegane, Hirokazu and Yachie, Akihiro},
 issue = {7},
 journal = {Pediatric Blood and Cancer},
 month = {Jul},
 note = {Primary Epstein-Barr virus (EBV) infection causes infectious mononucleosis and hemophagocytic lymphohistiocytosis (HLH) in children, where EBV infects B and CD8+ T cells, respectively. We measured pro-inflammatory and anti-inflammatory cytokines in both diseases. Significantly higher concentrations of various mediators, including interferon-γ, neopterin, interleukin (IL)-6, IL-10, IL-18, and heme oxygenase-1, were observed in EBV-HLH. Because of their similarity to the profile of familial HLH, this profile was likely a consequence of HLH, but not ectopic infection. TNF-α levels were elevated in both diseases. Elevation of those mediators may contribute to the disease pathogenesis of EBV-HLH by activating and inhibiting host immune responses. © 2013 Wiley Periodicals, Inc.},
 pages = {E46--E48},
 title = {Cytokine profiles in children with primary Epstein-Barr virus infection},
 volume = {60},
 year = {2013}
}