{"created":"2023-07-27T06:29:16.603732+00:00","id":14024,"links":{},"metadata":{"_buckets":{"deposit":"e36de3d7-1899-4c8a-8cf9-f471542e9c42"},"_deposit":{"created_by":3,"id":"14024","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14024"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014024","sets":["1132:1133:1134"]},"author_link":["23826","23827","413","23828","116","23829","62","585","520","22005","225"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"e92170","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The aim of this study was to examine the association between ectopic fat and organ-specific insulin resistance (IR) in insulin-target organs in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Organ-specific IR in the liver (hepatic glucose production (HGP)6fasting plasma insulin (FPI) and suppression of HGP by insulin [%HGP]), skeletal muscle (insulin-stimulated glucose disposal [Rd]), and adipose tissue (suppression of FFA by insulin [%FFA]) was measured in 69 patients with NAFLD using a euglycemic hyperinsulinemic clamp with tracer infusion ([6,6-2H 2]glucose). Liver fat, intramyocellular lipid (IMCL), and body composition were measured by liver biopsy, proton magnetic resonance spectroscopy, and bioelectrical impedance analysis, respectively. Results: HGPxFPI was significantly correlated with Rd (r = -0.57, P<0.001), %HGP with %FFA (r = 0.38, P<0.01), and Rd with %FFA (r = 0.27, P<0.05). Liver steatosis score was negatively associated with Rd (r = -0.47, P<0.001) as well as with HGPxFPI ( r = 0.43, P<0.001). Similarly, intrahepatic lipid was negatively associated with Rd (r = -0.32, P<0.05). IMCL was not associated with Rd (r = -0.16, P = 0.26). Fat mass and its percentage were associated with HGPxFPI (r = 0.50, P<0.001; r = 0.48, P<0.001, respectively) and Rd (r = -0.59, P<0.001; r = -0.52, P<0.001, respectively), but not with %FFA (r = -0.21, P = 0.10; r = -0.001, P = 0.99, respectively). Conclusion: Unexpectedly, fat accumulation in the skeletal muscle and adipose tissue was not associated with organ-specific IR. Instead, liver fat was associated not only with hepatic IR but also with skeletal muscle IR, suggesting a central role of fatty liver in systemic IR and that a network exists between liver and skeletal muscle. © 2014 Kato et al.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0092170","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"23826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamura, Toshinari"}],"nameIdentifiers":[{"nameIdentifier":"225","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00324111","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00324111"},{"nameIdentifier":"00324111","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00324111"},{"nameIdentifier":"00324111","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000324111"}]},{"creatorNames":[{"creatorName":"Takeshita, Yumie"}],"nameIdentifiers":[{"nameIdentifier":"585","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40507042","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40507042"},{"nameIdentifier":"40507042","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040507042"}]},{"creatorNames":[{"creatorName":"Ryu, Yasuji"}],"nameIdentifiers":[{"nameIdentifier":"22005","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50456414","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050456414"}]},{"creatorNames":[{"creatorName":"Misu, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"520","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80447680","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=80447680"},{"nameIdentifier":"80447680","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080447680"}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito"}],"nameIdentifiers":[{"nameIdentifier":"413","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60397213","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60397213"},{"nameIdentifier":"60397213","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60397213"},{"nameIdentifier":"60397213","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060397213"}]},{"creatorNames":[{"creatorName":"Tokuyama, Kumpei"}],"nameIdentifiers":[{"nameIdentifier":"23827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagasaka, Shoichiro"}],"nameIdentifiers":[{"nameIdentifier":"23828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuhisa, Munehide"}],"nameIdentifiers":[{"nameIdentifier":"23829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsui, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10019961","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10019961"},{"nameIdentifier":"10019961","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010019961"}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"62","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60185923","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60185923"},{"nameIdentifier":"60185923","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60185923"},{"nameIdentifier":"60185923","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060185923"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KATO-K-92170.pdf","filesize":[{"value":"323.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KATO-K-92170.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14024/files/ME-PR-KATO-K-92170.pdf"},"version_id":"397ce6ac-e1b0-4aca-ae27-8e54d4987695"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14024","relation_version_is_last":true,"title":["Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-06-20T07:08:33.983099+00:00"}