{"created":"2023-07-27T06:29:16.732519+00:00","id":14027,"links":{},"metadata":{"_buckets":{"deposit":"863f83ed-1ba3-40bd-82b0-09272c240c2c"},"_deposit":{"created_by":3,"id":"14027","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14027"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014027","sets":["1132:1133:1134"]},"author_link":["23834","23836","23835","22592","23839","20191","23832","23837","23833","514","23831","71","23838"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"939.e3","bibliographicPageStart":"931","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Experimental Hematology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To gain insight into the origin and clinical significance of leukocytes that lack human leukocyte antigen A (HLA-A) allele expression caused by a copy-number-neutral loss of heterozygosity in the short arm of chromosome 6 in patients with acquired aplastic anemia (AA), we used a high-sensitivity flow cytometry assay to investigate the presence of HLA-A allele-lacking leukocytes (HLA-LLs) in 144 AA patients. HLA-LLs, accounting for 0.2–99.8% of each leukocyte population, were detected in 18 of 71 (25.4%) newly diagnosed patients and in 25 of 73 (34.2%) previously treated patients. The lineage combination patterns of the HLA-LLs in the 43 HLA-LL+ patients were granulocytes (Gs), monocytes (Ms), B cells (Bs), and T cells (Ts; GMBT) in 13 cases, GMB in 16 cases, GM in 11 cases, and B alone in three cases. The response rate to antithymocyte globulin plus cyclosporine therapy (100%) and the 2-year, failure-free survival rate (100%) in 8 newly diagnosed HLA-LL+ patients were significantly higher than in 23 HLA-LL− patients (52.2% for both). These data suggest that HLA-LLs are a useful marker of the presence of immune pathophysiology in AA and that T-cell attacks against hematopoietic progenitor cells, rather than against hematopoietic stem cells, can trigger bone marrow failure in AA patients. © 2016 ISEH - International Society for Experimental Hematology","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.exphem.2016.05.013","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/0301472X","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Elsevier (CC-BY NC ND)"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00641088","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0301-472X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maruyama, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katagiri, Takamasa"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kashiwase, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiina, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato-Otsubo, Aiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zaimoku, Yoshitaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Maruyama, Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosokawa, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiyama, Ken"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamazaki, Hirohito"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Inoko, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Seishi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Shinji"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-MARUYAMA-H-931.pdf","filesize":[{"value":"624.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-MARUYAMA-H-931.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14027/files/ME-PR-MARUYAMA-H-931.pdf"},"version_id":"a7baf52d-1059-45ed-85c4-7831c0fddd83"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14027","relation_version_is_last":true,"title":["Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:54:15.416718+00:00"}