{"created":"2023-07-27T06:29:17.128722+00:00","id":14036,"links":{},"metadata":{"_buckets":{"deposit":"a55cb8bf-1266-4f4e-a051-20cc91b54364"},"_deposit":{"created_by":3,"id":"14036","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14036"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014036","sets":["1132:1133:1134"]},"author_link":["23860","23859","449","23861","334"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-09-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"18","bibliographicPageEnd":"3142","bibliographicPageStart":"3148","bibliographicVolumeNumber":"587","bibliographic_titles":[{"bibliographic_title":"FEBS Letters"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Covalently closed circular DNA (cccDNA) forms a template for the replication of hepatitis B virus (HBV) and duck HBV (DHBV). Recent studies suggest that activation-induced cytidine deaminase (AID) functions in innate immunity, although its molecular mechanism of action remains unclear, particularly regarding HBV restriction. Here we demonstrated that overexpression of chicken AID caused hypermutation and reduction of DHBV cccDNA levels. Inhibition of uracil-DNA glycosylase (UNG) by UNG inhibitor protein (UGI) abolished AID-induced cccDNA reduction, suggesting that the AID/UNG pathway triggers the degradation of cccDNA via cytosine deamination and uracil excision. © 2013 Federation of European Biochemical Societies.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.febslet.2013.07.055","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/00145793","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00642943","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-5793","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chowdhury, Sajeda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Kouichi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Simadu, Miyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koura, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muramatsu, Masamichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-03"}],"displaytype":"detail","filename":"ME-PR-KITAMURA-K-2013.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-KITAMURA-K-2013.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14036/files/ME-PR-KITAMURA-K-2013.pdf"},"version_id":"7a551381-144e-46eb-9191-feb425266103"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus"}]},"item_type_id":"4","owner":"3","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-03"},"publish_date":"2017-10-03","publish_status":"0","recid":"14036","relation_version_is_last":true,"title":["Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:54:02.452750+00:00"}