@article{oai:kanazawa-u.repo.nii.ac.jp:00014056,
 author = {齋藤, 裕人 and 尾山, 勝信 and 伏田, 幸夫 and 柄田, 智也 and 岡本, 浩一 and 中沼, 伸一 and 木下, 淳 and 牧野, 勇 and 中村, 慶史 and 林, 泰寛 and 井口, 雅史 and 中川原, 寿俊 and 宮下, 知治 and 藤田, 秀人 and 田島, 秀浩 and 高村, 博之 and 二宮, 致 and 北川, 裕久 and 藤村, 隆 and 太田, 哲生},
 issue = {6},
 journal = {Japanese Journal of Cancer and Chemotherapy},
 month = {Jul},
 note = {We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60-year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diag-nosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1 (DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy. 症例は60歳、男性。上腹部痛を主訴に受診。上部消化管内視鏡で胃体下部から前庭部の小弯後壁に易出血性の5型胃癌を認め、画像所見で傍大動脈・腸間膜リンパ節転移を認めた。生検にて腺癌成分と扁平上皮癌成分の混在を認めた。来院時より白血球数が著明に増多し、血清G-CSF高値、生検組織の免疫組織染色で腫瘍組織のG-CSF発現を認めた。以上よりG-CSF産生胃腺扁平上皮癌と診断し、化学療法（DCS (docetaxel/ cisplatin/ S-1併用)療法）を1コース行ったところ原発巣の縮小を認めたが、転移リンパ節の増大を認めた。急激な病状悪化により3ヶ月の経過で死亡した。},
 pages = {799--802},
 title = {急激な経過をとったG-CSF産生胃腺扁平上皮癌の１例},
 volume = {40},
 year = {2013}
}